Isis Pharmaceuticals, Inc. to Receive $26.5 Million from Alnylam Pharmaceuticals

Published: Jul 09, 2007

CARLSBAD, Calif., July 9 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. announced today that it will receive $26.5 million dollars from Alnylam Pharmaceuticals, Inc. as its portion of the upfront fees and equity premium in the recently announced transaction between Roche Holding AG and Alnylam. In addition, Isis has the potential to receive milestone and royalty payments. This transaction underscores the value of Isis' innovation and the leadership role Isis has played in the field of nucleic acid based therapeutics. The close of the agreement is subject to certain regulatory approvals and is expected to occur within approximately 30 days.

In 2004, Isis and Alnylam entered into a strategic relationship in which Alnylam obtained an exclusive license to Isis' intellectual property for double-stranded oligonucleotide therapeutics that mediate RNAi. In return, Isis received an upfront payment and financial participation in future transactions supported by Isis' patents.

"Isis' technology and intellectual property have proven to be critical in creating siRNAs with drug-like properties. The rapid advancement of RNAi therapeutics is in part due to the pioneering work of Isis in virtually every area of oligonucleotide technology," said John Maraganore, Ph.D., President and Chief Executive Officer of Alnylam.

Isis owns or controls more than 1,500 issued patents pertaining to nucleic acid based therapeutics. These patents have been exclusively licensed to Alnylam for double-stranded RNAi therapeutics and include, but are not limited to:

-- The Crooke Patents: U.S. 5,898,031 and 6,107,094 cover compositions, methods, and uses of modified oligonucleotides to inactivate a target mRNA mediated by a double-stranded RNase; -- Phosphorothioate and 2'-o-methyl modifications (Buhr, U.S. Patent No. 6,476,205); and, -- 2'-Ribose modifications (Cook, U.S. Patent Nos. 5,670,633; 6,005,087; 6,531,584; and 7,138,517).

"Since 2004 we have enjoyed a productive collaboration with Alnylam. Our technology supports both companies' leading drug discovery efforts in this new area of antisense. Working together we have made significant advances in RNAi technology and in creating drugs from this technology platform. Isis has benefited substantially from Alnylam's business development and financial successes. We look forward to additional successes from this valuable strategic relationship," said Stan Crooke, M.D., Ph.D., Chairman and Chief Executive Officer of Isis Pharmaceuticals, Inc. "Our pioneering efforts in developing nucleic acid based drugs have resulted in a very broad and valuable patent estate. The breadth and depth of our patent estate has allowed us to create a number of strategic relationships such as the one we have with

Alnylam that ensure our continued leadership in the field. This transaction further underscores the value of our innovation and strategy."


Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 17 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing drugs for cancer and inflammatory and other diseases. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,500 issued patents worldwide. Additional information about Isis is available at

This press release includes forward-looking statements regarding Isis Pharmaceuticals' business, its intellectual property portfolio, and the therapeutic and commercial potential of the Company's technologies. Any statement describing Isis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement, including those statements that are described as Isis' goals. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such products. Isis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Isis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Isis' programs are described in additional detail in Isis' annual report on Form 10-K for the year ended December 31, 2006, and its quarterly report on Form 10-Q for the quarter ended March 31, 2007, which are on file with the SEC. Copies of this and other documents are available from the Company.

In this press release, unless the context requires otherwise, "Isis," "Company," "we," "our," and "us" means Isis Pharmaceuticals and its subsidiaries.

Isis Pharmaceuticals, Inc.

CONTACT: Kate Corcoran, Ph.D., or Kristina Lemonidis, both of IsisPharmaceuticals, Inc., +1-760-603-2331

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