International Vaccine Experts Join AVM Board, Support COVID-19 Treatment
SEATTLE, June 10, 2020 /PRNewswire/ -- AVM Biotechnology announced today that Dr. Manon Cox and Dr. Gary Grohmann, both international experts on respiratory viruses and vaccine development, have joined AVM Biotechnology's Board of Directors. The decision to support AVM Biotechnology's AVM0703 by these two respected vaccine experts speaks to the potential for AVM0703 to be a global solution to the SARS-CoV2 (COVID-19) global pandemic.
Dr. Manon M.J. Cox, PhD, MBA
On joining the AVM Board, Dr. Cox said, "I am delighted to support AVM in its mission to develop affordable cures for unmet clinical needs. Our immune system is central to our health and powering up to fight foreign invaders may be the only way to deal with pandemic threats and aggressive cancers."
Dr. Gary Grohmann B. Sc. (Hons), PhD, FASM
Dr. Grohmann stated, "A vaccine to a human Coronavirus has never been made; and producing a vaccine to a newly emerging zoonotic virus such as COVID-19 (SARS-CoV-2), SARS-CoV-1, MERS-CoV, Nipah virus or Hendra virus is especially difficult as most of the novel platforms involved are largely untested in humans for safety and efficacy, and most approaches, whether they involve nucleic acid vaccines, viral -vectored vaccines, protein-based vaccines, live virus vaccines or inactivated virus vaccines, have no history of consistent reliable production or regulatory oversight. Moreover, most such attempts will likely fail at the clinical trial level as both arms of the immune response need to be activated for a vaccine to be truly effective. Furthermore, over time, it is expected that the virus will mutate, possibly rendering putative vaccines ineffective. It is also unknown how long any induced immunity will last and regular revaccination might be needed, assuming a licensed vaccine is made available. Finally, there are many other unknowns, including knowledge of the correlates of protection, the dose required, the concentration of antigen needed, safety and efficacy data, long term safety data, the need for an adjuvant and the shelf life of the vaccine. Normally, the endeavour to make a vaccine takes years of careful research followed by pre-clinical trials in animals and then trials in humans. It also requires vast investment and there is no guarantee of success.
"Drugs such as AVM0703 that mobilise endogenous supercharged natural killer cells, cytotoxic T cells and dendritic cells provide a potential solution for the treatment of seriously ill COVID-19 patients, are available, have safety data, and are registered for the treatment of other diseases. It is in this area that large scale studies should be undertaken as they can be used to immediately treat patients together with other interventions. Such drugs are also potentially useful in other infectious disease settings where vaccines and antiviral drugs are ineffective or unavailable."
About AVM Biotechnology and AVM0703
Why AVM0703 as a Treatment for COVID-19
AVM0703 is a strong candidate to usher in a new chapter of global viral containment and eradication.
Contact: Jena Dalpez Jdalpez@AVMbiotech.com
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SOURCE AVM Biotechnology, LLC