In Tough Biotech Market, Third Rock Raises New $1.1B Fund


Leading healthcare venture capital firm Third Rock Ventures announced a new fund Wednesday morning, Third Rock Ventures Fund VI, providing the company with $1.1 billion to invest in new life science companies. This brings Third Rock to a total of $3.8 billion across its venture funds.

Generally, 2022 has been a slow year for biotech investment. Despite the current stock market plunge, however, the space does appear to be showing signs of life. Although there has been relatively less activity in terms of mergers and acquisition and initial public offerings, venture capital firms have been more active.

“It’s been a challenging environment in the last few months,” Jeffrey Tong, Ph.D., venture partner at Third Rock, told BioPharma Dive. “But on the company creation side … we just have a very loyal base of [limited partners] who are investing across a long-term time horizon.”

Along with Tong, the partners investing in Fund VI are Abbie Celniker, Ph.D., Neil Exter, Kevin Gillis, Reid Huber, Ph.D., Dr. David Kaufman, M.D., Ph.D., Dr. Cary Pfeffer, M.D. and Dr. Robert Tepper, M.D., Ph.D.  

“An important differentiator for Third Rock is the strength and maturity of our ideation ecosystem,” Huber said in a statement. “Our discovery pipeline is as robust as it has ever been, and with our established and proven model for integrating deep scientific and medical expertise with operational and business acumen, we are uniquely positioned to advance these innovations to patients.”

Third Rock isn’t the only active venture firm. In March, Atlas Venture raised $450 million for its thirteenth fund, Atlas Venture Fund XIII. Investment partners include Jason Rhodes, Bruce Booth, Kevin Bitterman, Michael Gladstone, Jean-Francois Formela and David Grayzel.

Over the past two years, other big players have opened new funds. Flagship Pioneering raised $1.1 billion for its seventh “origination fund” in April 2020. Also in 2020, venBio Partners closed a $394 million life science venture capital fund, its third. Around the same time, ARCH Venture Partners announced two new venture capital funds for a combined total of $1.46 billion.

With the new fund, Third Rock indicated it plans to “invest in groundbreaking new companies from in the broader biotech ecosystem that are strongly aligned with Third Rock’s mission and strategy.”

Abbie Celniker, Ph.D., partner at Third Rock, said, “We believe that people are our greatest asset, and we invest significant effort and resources to ensure we hire the best people at Third Rock and across the portfolio. The internal team at Third Rock consists of ideators, experienced company builders, technology developers and domain experts critical to the success of developing companies.”

The firm’s portfolio boasts an impressive array of companies including Agios, Blueprint Medicines, bluebird bio, Abata Therapeutics, Editas Medicine, Decibel Therapeutics and many others.

Third Rock has enjoyed recent success. On Friday, June 10, one Third Rock company, Fulcrum Therapeutics, announced clinical proof-of-concept data from the ongoing Phase Ib study of FTX-6058 for sickle cell disease (SCD). The data included results from the first patients to receive a 6 mg dose of the therapy, an oral HbF inducer. It demonstrated a rapid and robust induction of HbF.

On the same day, the U.S. Food and Drug Administration’s Cell, Tissue and Gene Therapies Advisory Committee recommended two of bluebird bio’s lentiviral vector (LVV) gene therapies for approval. One is betibeglogene autotemcel (beti-cel) for beta-thalassemia. The other is elivaldogene autotemcel (eli-cel) for cerebral adrenoleukodystrophy, a devastating neurological disease affecting children.

On June 1, another Third Rock company, Asher Biotherapeutics, announced a clinical trial collaboration and supply deal with Merck for a Phase Ia/Ib study pairing AB248, Asher’s CD8-targeted interleukin 2 with Merck’s checkpoint inhibitor Keytruda (pembrolizumab) in locally advanced or metastatic solid tumors, including melanoma, renal cell carcinoma, non-small cell lung carcinoma and squamous cell carcinoma of the head and neck. The trial is expected to launch in the second half of this year.

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