Like the troublesome plaques and tangles of the demented brain, Alzheimer’s disease presents a knotted conundrum only now unravelling at the hands of science. The memory and cognitive problems brought by Alzheimer’s and similar diseases may come as the result of a breakdown in the brain’s stress response system, which normally protects the aging brain from such wasting. Li-Huei Tsai, director of the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology, praised the Harvard study as groundbreaking in a commentary published with the study in the journal Nature.
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