CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today the publication of pre-clinical research in the journal Molecular Therapy revealing key mechanisms related to the systemic delivery of RNAi therapeutics using lipid nanoparticles (LNPs). The new study (Akinc et al., Molecular Therapy, doi:10.1038/mt.2010.85, 2010), performed in collaboration with scientists at the Max Planck Institute of Molecular Cell Biology and Genetics and AlCana Technologies, Inc., describes a mechanism for endogenous apolipoprotein E (apoE)-mediated targeting of LNPs to the liver, demonstrates alternative ligand-directed targeting strategies for liver delivery of RNAi therapeutics, and highlights potential targeting approaches for delivery to tissues and cell types beyond the liver.
