NORTH BRUNSWICK, N.J.--(BUSINESS WIRE)--Advaxis, Inc. (OTCBB: ADXS), the live, attenuated Listeria monocytogenes (Lm) vaccine company, in collaboration with its scientific founder and Scientific Advisory Board Chair Dr. Yvonne Paterson, have shown that epitope spreading occurs in response to a form of the Company’s proprietary technology that targets tumor blood vessels (anti angiogenic antigen). Epitope spreading occurs when the immune system is able to attack antigens that are not the original target of an immune therapy but released from tumor cells killed by the therapy. By creating new targets in this way, the immune system can attack more antigens than the one for which the therapy was initially designed; thus, expanding the immune response against a tumor.
