GENEVA--(Marketwire - November 12, 2008) - Addex Pharmaceuticals (SWISS: ADXN) announced today that on November 11, 2008, S.R. One Ltd, the investment arm of GlaxoSmithKline plc, informed of reaching the threshold of 5.0% in the shareholding of Addex Pharmaceuticals Ltd. as the result of its acquisition in the market of shares. S.R. One said it had acquired a total of 293,125 registered shares, corresponding to 5.0% of the voting rights.