SYGNIS Pharma AG Receives Mandatory Offer Document from Dievini Hopp BioTech Holding GmbH & Co. KG

HEIDELBERG, Germany, December 23, 2008 - SYGNIS Pharma AG (Frankfurt: LIO; ISIN DE0005043509) today received the offer document relating to the mandatory offer by dievini Hopp BioTech holding GmbH & Co. KG. The document has been reviewed and approved by the German Federal Financial Supervisory Authority (BaFin). The SYGNIS management and supervisory board will publish a detailed response statement within the next few days.
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