Could the salt that preserves hot dogs also preserve your health? Scientists at the National Institutes of Health think so. They’ve begun infusing sodium nitrite into volunteers in hopes that it could prove a cheap but potent treatment for sickle cell anemia, heart attacks, brain aneurysms, even an illness that suffocates babies. Those ailments have something in common: They hinge on problems with low oxygen, problems the government’s research suggests nitrite can ease.Beyond repairing the reputation of this often maligned meat preservative, the work promises to rewrite scientific dogma about how blood flows, and how the body tries to protect itself when that flow is blocked. Indeed, nitrite seems to guard tissues — in the heart, the lungs, the brain — against cellular death when they become starved of oxygen.It doesn’t mean artery-clogging hot dogs are healthy.But the NIH researchers have filed for new patents on this old, overlooked chemical and are hunting a major pharmaceutical company to help develop it as a therapy — even as doctors await the enrollment of sick patients into research studies in coming months. The scientists are so convinced of nitrite’s promise that lead researcher Dr. Mark T. Gladwin says the government will pursue drug development on its own if necessary.
