COLUMBIA, Md., July 7, 2009 — Shimadzu Scientific Instruments introduces PTM Finder™ software which uses data mining to investigate post-translational modifications in complex protein samples, including data for hypothetical, novel modifications. The software is designed to integrate with Shimadzu’s AXIMA™ line of MALDI mass spectrometers.
With PTM Finder software, users can identify peptide sequences carrying one or more modifications using MS/MS data. The software facilitates consecutive Mascot searches using all the functionality of MS/MS Ion Search.
Peptides that do not match any proteins during the searches are directed toward a “PTM Define” module where users define their own hypothetical modifications and screen the remaining MS/MS data for specific shifts in fragment masses, neutral losses and/or diagnostic ions. Such searches are quick and thorough, as they are performed based on a reduced database of protein sequences.
Users can easily import amino acid sequences with a simple copy/paste function or use the proteins derived from the initial Mascot search results, giving more flexibility to search for PTMs whether or not they know the protein they are using.
For more information on PTM Finder software or the AXIMA line of MALDI mass spectrometers, visit www.ssi.shimadzu.com/products/products.cfm?subcatlink=maldimass.
About Shimadzu Scientific Instruments, Inc.
Shimadzu Scientific Instruments (SSI) is the American subsidiary of Shimadzu Corporation, headquartered in Kyoto, Japan. Founded in 1875, Shimadzu is a $2 billion multinational corporation with three major divisions: Medical Diagnostics, Aerospace/Industrial and Analytical Instruments. The Analytical Division is one of the world's largest manufacturers of analytical instrumentation and environmental monitoring equipment. In 1975, SSI corporate headquarters was established in Columbia, Md. to provide analytical solutions to laboratories in North, Central and parts of South America. In the U.S., SSI has a network of more than 50 locations providing local and regional sales, service, and technical support.
With PTM Finder software, users can identify peptide sequences carrying one or more modifications using MS/MS data. The software facilitates consecutive Mascot searches using all the functionality of MS/MS Ion Search.
Peptides that do not match any proteins during the searches are directed toward a “PTM Define” module where users define their own hypothetical modifications and screen the remaining MS/MS data for specific shifts in fragment masses, neutral losses and/or diagnostic ions. Such searches are quick and thorough, as they are performed based on a reduced database of protein sequences.
Users can easily import amino acid sequences with a simple copy/paste function or use the proteins derived from the initial Mascot search results, giving more flexibility to search for PTMs whether or not they know the protein they are using.
For more information on PTM Finder software or the AXIMA line of MALDI mass spectrometers, visit www.ssi.shimadzu.com/products/products.cfm?subcatlink=maldimass.
About Shimadzu Scientific Instruments, Inc.
Shimadzu Scientific Instruments (SSI) is the American subsidiary of Shimadzu Corporation, headquartered in Kyoto, Japan. Founded in 1875, Shimadzu is a $2 billion multinational corporation with three major divisions: Medical Diagnostics, Aerospace/Industrial and Analytical Instruments. The Analytical Division is one of the world's largest manufacturers of analytical instrumentation and environmental monitoring equipment. In 1975, SSI corporate headquarters was established in Columbia, Md. to provide analytical solutions to laboratories in North, Central and parts of South America. In the U.S., SSI has a network of more than 50 locations providing local and regional sales, service, and technical support.
