Sleep apnea occurs when the muscles in the back of the throat relax during sleep, leading the airway to narrow or close. It’s estimated that 12 million Americans are affected by sleep apnea, but it’s widely believed that the issue is under reported. There are no blatant signs or blood tests to diagnose the disrupted sleep. Most cases of sleep apnea are discovered when a partner notices an increase in snoring, or when the sufferer indicates daytime fatigue and sleepiness.
To learn more about sleep apnea, the National Institutes of Health awarded University of Missouri researchers a $2.83 million multi-investigator grant to continue work on neurohumoral control of the circulation and breathing– studying how the brain responds to hypoxia, or the lack of oxygen. The team includes Eileen Hasser, professor in the Department of Biomedical Sciences and adjunct professor of medical pharmacology and physiology; Cheryl Heesch, professor in the Department of Biomedical Sciences; and David Kline, assistant professor in the Department of Biomedical Sciences.
The researchers use an experimental model of lab rats that produces traits that mimic periodic sleep apnea. Using state-of-the-art techniques and equipment in the MU Dalton Cardiovascular Research Center, the researchers are able to identify specific cells and pathways within the brain that are involved in responses to hypoxia. Researchers hope the information can be used to develop drugs or procedures to correct or slow the dangerous effects of sleep apnea.
“Working together, we each bring different skills and ways of looking at the problem, which increases our ability to answer the important questions in this field,” Hasser said.
While only in the first year of the four-year grant, the researchers have already advanced knowledge on how the brain adapts to diminished oxygen. Results of their initial experiments were recently published in the scientific journal, Neuroscience.
