Telos® 2 Reagent Chips from Dolomite Microfluidics have helped San Francisco-based ProLynx LLC to develop a novel drug delivery platform. Jeff Henise, Director of Process Development at ProLynx, explained: “Traditional polymer encapsulation delivery systems rely on diffusion or breakdown of the polymer to release their payload. In contrast, our drug delivery system offers controlled release using self-cleaving linkers to attach the drug to hydrogel microsphere carriers. Drug release and subsequent gel degradation depend only on the cleavage rate of the linker, and are tunable across a wide range. A key part of our manufacturing process is the production of the hydrogel as microspheres, which is carried out using Telos 2 Reagent Chips.”
“To produce microspheres of the correct size, we use a microfluidics approach and a custom-made Telos chip with a 50 micrometer channel. This chip is robust, with excellent chemical compatibility, and offers a high throughput for its size. Although there are other ways of making emulsions, microfluidics offers better control of particle size and a high yield of monodisperse emulsion. As the resulting material does not need to be screened to remove incorrectly-sized particles, this minimizes waste and increases yield by as much as 30 percent.”
For more information, visit www.dolomite-microfluidics.com/webshop/telos-droplet-manufacture-telos-chips-c-72_74
About Dolomite
Established in 2005, Dolomite Microfluidics has grown to be the world leader in the design and manufacture of high quality innovative microfluidic products.
The company offers a broad range of modular microfluidic systems, modules and components – including pumps, chips, connectors, temperature controllers, sensors, accessories and custom-made components – as well as software for analysis or automation.
Modularity, ease of use, innovation and scalability are common to all Dolomite products, which are used across a broad range of applications in biology, drug discovery, chemistry, food, cosmetics and academia.
Dolomite is a part of the Blacktrace group of companies, a world leader in Productizing Science®, and has offices in the USA, Japan, India and Brazil, as well as a worldwide network of distributors.
