NEWTON, Mass.--(BUSINESS WIRE)--Pro-Pharmaceuticals, Inc. (Amex: PRW), a developer of novel carbohydrate compounds, today announced it has submitted an Orphan Drug Status application to the European Medicines Agency (EMEA) for DAVANAT® to be co-administered with 5-Fluorouracil (5-FU) to treat cholangiocarcinoma (bile duct cancer) patients.