PRINCETON, N.J., Nov. 1 /PRNewswire-FirstCall/ -- Pharmacopeia today announced results for the quarter and nine months ended September 30, 2007, and highlighted several important developments in its therapeutic programs and corporate milestones achieved since the beginning of the quarter.
Subsequent to the end of the third quarter:
Pharmacopeia announced that it has licensed a Phase 1 selective androgen receptor modulator (SARM) program from BMS, including lead and back-up compounds. Pharmacopeia plans to develop the lead compound from this program, PS178990, as a potential novel treatment for muscle wasting associated with a number of serious chronic and acute medical conditions such as surgical and severe burn recovery, end-stage renal disease and cancer- and AIDS-related cachexia. The SARM program has a broad portfolio of pending patent applications that, if granted, would provide intellectual property coverage to the SARM program through at least 2023. PS178990 has been well characterized by BMS both in pre-clinical studies and in a Phase 1 single ascending dose study. The company plans to conduct several Phase 1 studies in 2008, including a multiple ascending dose study of PS178990, to obtain additional safety and tolerability data before entering Phase 2.
In consideration for the SARM program license, Pharmacopeia will apply a portion of its medicinal chemistry resources to an unrelated BMS discovery program for up to three years. While the company is still evaluating the accounting treatment for its acquisition of the SARM program, it expects to record a non-cash charge to earnings ranging from $9.5 million to $10.0 million in the fourth quarter of 2007. This charge relates to the estimated fair value of the chemistry resources the company is to provide to BMS. In addition the company will pay BMS milestone payments associated with submission and approval of a therapeutic product for marketing and a stepped royalty on net sales of therapeutic products, if any, resulting from the SARM development program.
“Our recent clinical progress with PS433540 as well as the in-licensing of our new SARM program has significantly enhanced Pharmacopeia’s pipeline,” stated Les Browne, Ph.D., Pharmacopeia’s President and Chief Executive Officer. “We now have two of our own programs in clinical development as well as two partnered programs advancing in Phase 2 clinical development that should yield results on efficacy in 2008.”
THIRD QUARTER, 2007 FINANCIAL RESULTS
At September 30, 2007, Pharmacopeia had cash, cash equivalents and marketable securities of $81.4 million. As previously stated, Pharmacopeia expects to end the year with $65 million to $70 million in cash and short-term investments.
Pharmacopeia’s net revenue was $5.1 million for the quarter ended September 30, 2007, compared to $6.3 million for the quarter ended September 30, 2006. The decrease in revenue during the quarter ended September 30, 2007 was primarily due to lower milestone revenue as compared to the prior year period, offset by increased research revenue from Pharmacopeia’s alliances with GSK, Organon and Wyeth. For the nine months ended September 30, 2007, net revenue was $16.4 million, compared to $13.7 million for the same period in 2006. The increase in net revenue during the nine-month period was largely due to research revenue recorded from Pharmacopeia’s alliances with Cephalon, GSK and Wyeth.
Collaborative research and development expense increased 67% to $5.8 million in the three months ended September 30, 2007, compared to $3.4 million in the three months ended September 30, 2006. This increase was due to increased resources allocated to Pharmacopeia’s alliance with GSK, coupled with resources expended on the company’s JAK3 program. The expense for the JAK3 program has been primarily classified as collaborative research and development expense since the company partnered the program with Wyeth in December 2006. Prior to 2007, resources expended on the company’s JAK3 program were classified as proprietary research and development expense. For the nine months ended September 30, 2007, collaborative research and development expense increased 71% to $16.7 million, compared to $9.8 million for the same period in 2006. This increase was due to increased resources allocated to Pharmacopeia’s alliances with Cepahlon, GSK and Wyeth.
The company incurred proprietary research and development expense of $9.5 million in the quarter ended September 30, 2007, compared to $5.8 million in the same period in 2006, an increase of 64%. For the nine months ended September 30, 2007, proprietary research and development expense increased to $22.0 million, compared to $17.6 million for the same period in 2006, an increase of 25%. These increases related primarily to costs for clinical trials for PS433540, including milestone payments to BMS of $2.0 million and $3.0 million, in the three- and nine-month periods ended September 30, 2007, respectively. These increases were offset by the reclassification of costs incurred on the company’s JAK3 program since partnering the program with Wyeth.
General and administrative expense was $2.6 million for the quarter ended September 30, 2007, compared to $2.1 million for the same period in 2006, an increase of 20%. General and administrative expense was $8.0 million for the nine months ended September 30, 2007, compared to $7.0 million for the same period in 2006, an increase of 15%. These increases were largely due to higher consulting and recruiting costs.
Pharmacopeia reported a net loss of $11.7 million, or $0.40 per basic and diluted share, for the quarter ended September 30, 2007. The company recorded a net loss of $4.7 million, or $0.31 per basic and diluted share, for the same quarter in 2006. For the nine months ended September 30, 2007, Pharmacopeia recorded a net loss of $28.6 million, or $1.07 per basic and diluted share. Pharmacopeia recorded a net loss of $19.6 million, or $1.28 per basic and diluted share for the 2006 nine-month period.
Further details regarding Pharmacopeia’s third quarter 2007 results will be presented in a conference call today, November 1, 2007, at 5:00 p.m. Eastern time. Dr. Leslie J. Browne, President and Chief Executive Officer, Mr. Brian M. Posner, Executive Vice President and Chief Financial Officer, and Dr. Rene Belder, Vice President, Clinical and Regulatory Affairs, will host the call. Forward-looking and material information may be discussed on this conference call.
Webcast information can be accessed by visiting http://www.pharmacopeia.com
A replay of the conference call can be accessed by dialing toll-free (888) 203-1112 in the U.S., or (719) 457-0820 outside the U.S. The access code for the replay is 9745493. A replay of the webcast will also be accessible on Pharmacopeia’s website on the “Investors” page at http://www.pharmacopeia.com. The replays will be available for two weeks.
ABOUT PHARMACOPEIA
Pharmacopeia is a clinical development stage biopharmaceutical company dedicated to discovering and developing novel small molecule therapeutics to address significant medical needs. The company has a broad portfolio of clinical and preclinical candidates under development internally or by partners including seven clinical compounds in Phase 2 or Phase 1 development addressing multiple indications including hypertension, diabetic nephropathy, muscle wasting, inflammation and respiratory disease. The company is leveraging its fully integrated drug discovery platform to sustain the growth of its development pipeline. Pharmacopeia has established strategic agreements with major pharmaceutical and biotechnology companies, including Bristol-Myers Squibb, Cephalon, GlaxoSmithKline, Organon, Schering-Plough, and Wyeth Pharmaceuticals. For more information please visit the company’s website at http://www.pharmacopeia.com.
This press release, and oral statements made with respect to information contained in this press release, constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those which express plan, anticipation, intent, goal, contingency or future development and/or otherwise are not statements of historical fact. These statements are based upon management’s current expectations and are subject to risks and uncertainties, known and unknown, which could cause actual results and developments to differ materially from those expressed or implied in such statements. These forward- looking statements include, but are not limited to, statements about the successful implementation of Pharmacopeia’s strategic plans, Pharmacopeia’s plans to develop PS433540, a product candidate from its DARA program, Pharmacopeia’s Phase 2 and Phase 1 clinical studies with respect to PS433540, including timing and expected outcomes of such studies, Pharmacopeia’s plans to develop PS178990, a product candidate from its SARM program, Pharmacopeia’s Phase 1 clinical studies with respect to PS178990, including timing and expected outcomes of such studies, Pharmacopeia’s estimates of the market opportunities for its product candidates, including PS433540 and PS178990, Pharmacopeia’s ability to successfully perform under its collaborations with Bristol-Myers Squibb, Cephalon, GlaxoSmithKline, Organon and Wyeth, Pharmacopeia’s ability to build its pipeline of novel drug candidates through its own internally-funded drug discovery programs, third party collaborations and in-licensing, Pharmacopeia’s ability to raise additional capital, Pharmacopeia’s expectations concerning the development priorities of its collaborators, their ability to successfully develop compounds and its receipt of milestones and royalties from the collaborations, Pharmacopeia’s anticipated operating results, financial condition, liquidity and capital resources, Pharmacopeia’s expectations concerning the legal protections afforded by U.S. and international patent law, Pharmacopeia’s ability to pursue the development of new compounds and other business matters without infringing the patent rights of others, additional competition, and changes in economic conditions.
Further information about these and other relevant risks and uncertainties may be found in Pharmacopeia’s Reports on Form 8-K, 10-Q and 10-K filed with the U.S. Securities and Exchange Commission. Pharmacopeia urges you to carefully review and consider the disclosures found in its filings which are available in the SEC EDGAR database at http://www.sec.gov and from Pharmacopeia at http://www.pharmacopeia.com. All forward-looking statements in this press release and oral statements made with respect to information contained in this press release are qualified entirely by the cautionary statements included in this press release and such filings. These risks and uncertainties could cause actual results to differ materially from results expressed or implied by such forward-looking statements. These forward-looking statements speak only as of the date of this press release. Pharmacopeia undertakes no obligation to (and expressly disclaims any such obligation to) publicly update or revise the statements made herein or the risk factors that may relate thereto whether as a result of new information, future events, or otherwise.
CONTACT: Brian M. Posner, Executive Vice President and Chief Financial
Officer of Pharmacopeia, +1-609-452-3643
Web site: http://www.pharmacopeia.com/
