Results showed that patients experienced clinically significant improvements in headache disability and quality of life, and demonstrated that SPG stimulation may reduce the frequency of cluster attacks. Autonomic Technologies, Inc. (ATI), the developer of the ATI Neurostimulation System designed for the treatment of severe headaches, today announced results of their clinical study in cluster headache, now published online in Cephalalgia.1 The robust, multi-centre, randomized, placebo-controlled clinical study is the largest study performed with a medical device for cluster headache.