Authors studied lab results for 28 million Americans with the highest risk and found most are not getting recommended tests to detect life-threatening disease
Authors studied lab results for 28 million Americans with the highest risk and found most are not getting recommended tests to detect life-threatening disease |
| [05-August-2021] |
| NEW YORK, Aug. 5, 2021 /PRNewswire/ -- New data suggest that millions of patients most at-risk for life-threatening kidney disease are unaware they have it because they are not tested according to clinical practice guidelines despite their risk. The study, by authors from the National Kidney Foundation (NKF) and LabCorp, appears today in the journal Diabetes Care.
The common eGFR test alone is insufficient for kidney disease detection, said NKF Chief Medical Officer Joseph Vassalott. In the study, “Chronic Kidney Disease Testing (CKD) Among At-Risk Adults in the U.S. Remains Low: Real-World Evidence from a National Laboratory Database,” investigators reviewed laboratory ordered CKD tests from more than 28 million patients with diabetes, hypertension (also known as high blood pressure), or both, that were tested by Labcorp between 2013 and 2018. Researchers found that 80.3 percent of these patients had not received testing according to Kidney Disease Improving Clinical Outcomes (KDIGO) guidelines: a urine test, known as the albumin-creatinine ratio (uACR), along with a blood test, known as the estimated glomerular filtration rate (eGFR). The combined tests are known as the Kidney Profile and test protein levels in urine and waste in the blood. By measuring these levels, physicians can gauge kidney function and damage. “The common eGFR test alone is insufficient for kidney disease detection,” said NKF Chief Medical Officer Joseph Vassalotti, MD, and co-author of the study. “Both the eGFR blood test for kidney function and the uACR urine test for albumin, a type of protein, should be performed at least annually for at-risk patients by primary care physicians and other clinicians who manage diabetes and hypertension, such as endocrinologists and cardiologists.” An estimated 37 million adults in the United States have kidney disease and about 90 percent remain unaware of the condition. The top risk factors for kidney disease are diabetes and high blood pressure, as well as obesity, heart disease, and family history of kidney disease. “This large retrospective analysis provides real-world evidence that rates of guideline-concordant CKD testing in at-risk patients remain low and did not improve much over the studied period,” said David Alfego, PhD, Labcorp senior data scientist and the paper’s other co-author. “As the at-risk population grows because of increases in diabetes, hypertension and obesity, it is imperative to identify and treat early kidney disease.” Kidney disease often has no detectable symptoms by the patient, and too often patients only find out they have the disease when their kidneys fail. Yet, most at-risk patients are not receiving regular and complete testing for the disease, especially in the primary care setting that represents the front-line in CKD detection and management. Early detection is critical to slowing the disease progression. Lifestyle changes, dietary modifications, medical management of risk factors, and therapeutics that protect the kidney can slow kidney disease progression and help protect against cardiovascular complications that are associated with advanced kidney disease. “Kidneys don’t get the attention they should,” Dr. Vassalotti said. “Kidneys don’t cough. Kidney disease is largely asymptomatic, so patients don’t realize they have it. Since most people living with kidney disease are seen in a primary care setting, these professionals have an opportunity to improve kidney diagnosis that will in turn increase awareness and patient engagement and inform therapeutic interventions.” Removing barriers to proper testing while also raising awareness among adults about the need for the annual Kidney Profile are also critical to reversing the underdiagnosis of the disease, the study concluded. In 2019, NKF launched the Are You the 33%?® awareness campaign with a simple quiz to determine kidney disease risk and tools they can use to talk to the primary care physicians. The campaign is part of NKF’s mission to raise awareness and decrease prevalence of the disease. To read the study visit: https://care.diabetesjournals.org/lookup/doi/10.2337/dc21-0723. The authors of this study are: David Alfego, Ph.D., Jennifer Ennis, M.D., Barbara Gillespie, M.D., Mary Jane Lewis, B.S., Elizabeth Montgomery, B.S., Silvia Ferrè, Ph.D., Joseph A. Vassalotti, M.D., Stanley Letovsky, Ph.D. Kidney Disease Facts About the National Kidney Foundation About Labcorp
SOURCE National Kidney Foundation | ||
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