KUUSISTO, Finland, September 21 /PRNewswire/ -- Metkinen Chemistry today announced new products in the range of the ultra-pure purine nucleoside analogs used in the development of oligonuceotide therapeutics and in research applications. The new products, namely 3'- Amino-2',3'-A and G nucleosides serve as building blocks for oligonucleotides, which are resistant to enzymatic degradation.
Another set of new nucleosides - 2'-deoxy-2'-fluoro-A and G, as well as 2'-deoxy-2'-amino-A and G are popular building clocks for the stabilization of small interfering RNAs (siRNAs) and aptamers.
Biotransformation technology
Currently, the production of purine nucleoside analogues by chemical routes is time-consuming, complicated and expensive. However, Metkinen Chemsitry’s biotransformation technology addresses the problems of traditional synthetic routes and offers alternative methods of biotransformation.
Their proprietary technology offers stereo and region selectivity, superior efficiency and low waste. The breakthrough was achieved last year by scaling up production of 3'-deoxy-3' amino ribonucleosides. Subsequently Metkinen Chemistry has succeeded in scaling up production of 2'-deoxy-2'- fluoroadenosine (2'-Fluoro A) and 2'-deoxy-2'-fluoroguanosine (2'-Fluoro G).
“We were very excited to prove the fact that our technology is easily adaptable for the production of about 30 different purine analogues”, commented Alex Michine, Managing Director of Metkinen Chemistry. “That means previously prohibitively expensive purine nucleosides are now available in bulk quantities and are very attractively priced. We really hope that the availability of purine 2' -fluoronucleosides will facilitate promising advances in siRNA and aptamer research”.
About Metkinen Chemistry (www.metkinenchemistry.com) Metkinen Chemistry is a Finnish company engaged in the research and production of reagents of DNA /RNA synthesis. To learn more about Metkinen Chemistry’s products visit its web site at http://www.metkinenchemistry.com
Metkinen Chemistry
CONTACT: Contact: Alex Michine, Managing Director, Metkinen Chemistry,+358-40-543-37-40, alex.michine@metkinen.inet.fi. PR Contact: VilleLehtovirta, Text 100 Conexio, +358-50-346-6946, ville.lehtovirta@conexio.fi
