Medco Health Solutions Inc (MHS.N) and AstraZeneca Plc (AZN.L) were subpoenaed by the U.S. Department of Justice over their relationship involving four of AstraZeneca’s drugs, including widely used acid reflux medicines Nexium and Prilosec. The companies said separately on Tuesday they received the subpoenas this month. They were issued from the U.S. attorney’s office for the District of Delaware, the state which is also home to AstraZeneca’s U.S. headquarters. News of the investigation comes at a sensitive time for Medco, which agreed last week to be bought by Express Scripts Inc (ESRX.O) for $29.1 billion.