The sodium glucose co-transporter 2 (SGLT2) inhibitor ertugliflozin does not impact the likelihood of heart attack, stroke, or cardiac death in patients with type 2 diabetes (T2D) and established cardiovascular (CV) disease, according to data presented today
| CHICAGO, June 16, 2020 /PRNewswire/ -- The sodium glucose co-transporter 2 (SGLT2) inhibitor ertugliflozin does not impact the likelihood of heart attack, stroke, or cardiac death in patients with type 2 diabetes (T2D) and established cardiovascular (CV) disease, according to data presented today. Research also showed the rate of hospitalization for heart failure was lower among study participants treated with ertugliflozin. The study was highlighted during the “Results of the eValuation of ERTugliflozin EffIcacy and Safety CardioVascular Outcomes Trial (VERTIS-CV)” symposium at the American Diabetes Association’s (ADA’s) 80th Virtual Scientific Sessions.
Ertugliflozin, a relatively new member of the SGLT2 inhibitor class of medications, is prescribed as an adjunct medication to diet and exercise to improve glycemic control in adults with T2D. The VERTIS CV Study was an international phase 3, randomized, parallel-group study to determine the CV safety of ertugliflozin compared to placebo. Beginning in 2013, the study enrolled 8,246 participants with T2D throughout the U.S. and 34 countries worldwide who were aged 40 and older and had a documented history of atherosclerosis involving the coronary, cerebral, or peripheral vascular systems. The patients were randomly assigned to take either ertugliflozin 15 mg (n= 2747), ertugliflozin 5 mg (n=2752), or a placebo (n= 2747), once daily. Participants were followed for up to 6.1 years to assess the time to the first occurrence of major adverse CV events, including CV death, non-fatal myocardial infarction, or non-fatal stroke (the primary outcome of the study). Results of the study indicated:
“While we hypothesized that we would have shown more significant preventive cardiovascular benefits, the overall pattern of benefit is consistent with what has been seen with other drugs in this class,” said Christopher Cannon, MD, lead VERTIS-CV researcher, professor of medicine at Harvard Medical School, senior physician in the Cardiovascular Division at Brigham and Women’s Hospital, and education director at the Cardiovascular Innovation Group1. “Our research supports the recent guideline updates indicating the use of this class of drugs for patients with diabetes who have prior atherosclerotic heart disease, heart failure, or chronic kidney disease. Patients with type 2 diabetes who have heart disease should discuss with their doctor whether SGLT2 inhibitors may be appropriate for their treatment.” Research presentation details:
For more information or to request an interview with Dr. Cannon, please contact Daisy Diaz by phone at (703) 253-4807 or by email at SciSessionsPress@diabetes.org. About the ADA’s Scientific Sessions About the American Diabetes Association 1 Disclosures: Dr. Cannon has received research grants and honoraria from Merck and Pfizer, the trial sponsors. In addition, he has received research grants from Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Janssen, as well as honoraria from Aegerion, Alnylam, Amarin, Amgen, Applied Therapeutics, Ascendia, Boehringer Ingelheim, Bristol-Myers Squibb, Corvidia, HLS Therapeutics, Innovent, Janssen, Kowa, and Sanofi. Contact: Daisy Diaz
SOURCE American Diabetes Association |
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