AURORA, ON, May 3 /PRNewswire-FirstCall/ - Helix BioPharma Corp. announced today the issuance of a patent (U.S. Patent # 7,211,250) from the United States Patent & Trademark Office relating to the method and composition in combining DOS47 with targeting agents in the treatment of cancer. Helix is currently developing its first DOS47-based cancer therapeutic, L-DOS47, a drug product candidate for the treatment of adenocarcinoma of the lung.
“This patent provides Helix with significant intellectual property protection and is a vital step toward our goal of bringing DOS47-based cancer therapeutics to market,” said Donald H. Segal, President and CEO of Helix. “We will continue to advance our worldwide DOS47 patent strategy in support of the development of L-DOS47 with a view to maximizing the commercial opportunity of this product and future products derived from our DOS47 technology platform.”
Preliminary in vitro and in vivo testing of L-DOS47 has been completed with certain research findings presented in peer-reviewed publications, posters and scientific meetings. See our website at www.helixbiopharma.com for further information on these publications, posters and meetings. In addition, Helix has begun scale-up manufacturing of L-DOS47 for the Company’s upcoming preclinical and clinical testing initiatives.
“Though we are focused on L-DOS47 as our first DOS47-based cancer therapeutic, we continue to explore other cancer-specific targeting agents with the goal of developing a portfolio of conjugated DOS47-based cancer therapeutics,” commented Dr. Heman Chao, Helix’s Vice President of Research.
About L-DOS47
L-DOS47 combines Helix’s proprietary DOS47 new drug candidate with a highly specific single domain antibody, to form a potential new targeted drug product for the treatment of adenocarcinoma of the lung, the most common form of cancer in the world today. L-DOS47 is thought to function by leveraging a natural process in the body called the urea cycle, to produce an anti-cancer effect. It is based upon a naturally occurring enzyme called urease that essentially reverses the urea cycle by breaking down urea into metabolites that include ammonia and hydroxyl ions. By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells in a manner that leads to their death. Among these theorized effects, L-DOS47 is believed to stimulate an increase in the pH of the microenvironment surrounding the cancerous cells, effectively reversing the acidic extra-cellular conditions that are known to be necessary for cancer cell survival. As well, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions.
About Helix BioPharma Corp.
Helix BioPharma Corp. is a biopharmaceutical company specializing in the field of cancer therapy. The Company is actively developing innovative products for the prevention and treatment of cancer based on its proprietary technologies. Helix’s product development initiatives include its Topical Interferon Alpha-2b, for the treatment of conditions caused by the human papilloma virus, and its novel L-DOS47 new drug product candidate for the treatment of lung adenocarcinoma. Helix is listed on the Toronto Stock Exchange under the ticker symbol “HBP”.
The Toronto and Frankfurt Stock Exchanges have not reviewed and do not accept responsibility for the adequacy or accuracy of the content of this News Release. This News Release contains certain forward-looking statements and information regarding Helix’s DOS47 drug development program. Forward-looking statements and information can be identified by the use of forward-looking terminology such as “developing”, “goal”, “will”, “continue”, “with a view to”, “future”, “potential”, “is thought”, “is believed”, “new”, “will”, “theorized”, or variations thereon or comparable terminology referring to future events or results. Forward looking statements and information are statements and information about the future and are inherently uncertain, and Helix’s actual results could differ materially from those anticipated in these forward-looking statements as a result of numerous factors, including without limitation, uncertainty whether L-DOS47 will be developed successfully as a drug or at all; uncertainty whether DOS47 will be developed as a therapeutic for any other cancers; the risk that the U.S. patent referred to in this News Release may be challenged and that the patent, or a portion of it, may subsequently be struck down; research & development risks, including the risk that early R&D results may not be repeated in later R&D; the risk of technical obsolescence; the need for regulatory approvals, which may not be obtained in a timely matter or at all; the need for clinical trials, the occurrence and success of which cannot be assured; intellectual property risks; the need to manufacture to regulatory standards and risks inherent in upscaling; marketing and partnership/strategic alliance risks; the effect of competition; Helix’s need for additional future capital, which may not be available in a timely manner or at all, as well as a description of other risks and uncertainties affecting Helix and its business, as contained in Helix’s latest Annual Information Form and other filings with the Canadian Securities Regulatory Authorities at www.sedar.com, any of which could cause actual results to vary materially from current results or Helix’s anticipated future results. Forward-looking statements and information are based on the beliefs, opinions and expectations of Helix’s management at the time they are made, and Helix does not assume any obligation to update any forward-looking statement or information should those beliefs, opinions or expectations, or other circumstances change.
Helix BioPharma Corp.
CONTACT: Investor Relations, Christina Bessant, The Equicom Group Inc.,Tel: (416) 815-0700 ext. 269, (800) 385-5451, Fax: (416) 815-0080, Email:cbessant@equicomgroup.com; Media Relations, Matthew Haines, Russo PartnersLLC, Tel: (212) 845-4235, Fax: (212) 845-4260, Email:matthew.haines@russopartnersllc.com, www.russopartnersllc.com
