Foresight Diagnostics, a leader in molecular cancer diagnostics, announced the presentation of a study in collaboration with a leading cancer center at the upcoming annual meeting of the American Association for Cancer Research (AACR).
| AURORA, Colo., April 4, 2023 /PRNewswire/ -- Foresight Diagnostics, a leader in molecular cancer diagnostics, announced the presentation of a study in collaboration with a leading cancer center at the upcoming annual meeting of the American Association for Cancer Research (AACR).
The poster, titled “Ultrasensitive ctDNA minimal residual disease monitoring in early NSCLC with PhasED-Seq,” describes the results of a study evaluating the performance of the Foresight Solid Tumor Recurrence Test in patients with lung cancer. The test, a clinical diagnostic tool for minimal residual disease (MRD) monitoring based on PhasED-Seq technology, achieved an LOD95 of less than one part-per-million in the majority of plasma samples analyzed. Compared to a first generation ctDNA MRD approach tracking single nucleotide variants, the Foresight Solid Tumor Recurrence Test achieved an approximately two-fold improvement in clinical sensitivity for MRD detection in the first blood sample collected following completion of therapy in patients who later experienced recurrence. Although PhasED-Seq has previously been validated in MRD monitoring for lymphomas, this study is the largest demonstration to date of the clinical applicability of PhasED-Seq-based MRD monitoring in solid tumors. Thanks to PhasED-Seq’s superior sensitivity for detecting ctDNA, this technology can reduce the rate of false negative results, giving patients and clinicians more accurate information and greater peace of mind. Improved sensitivity may also allow for more advance warning of recurrent disease. “We are pleased to share these promising results from our study in collaboration with Foresight Diagnostics. This study provides some of the first evidence that PhasED-Seq’s superior analytical sensitivity for MRD detection could translate into clinical benefit for patients with lung cancer,” said Dr. James M. Isbell, Co-Director of the Thoracic Liquid Biopsy Program at Memorial Sloan Kettering Cancer Center (MSK) and the lead investigator for the study. Jake Chabon, CEO and co-founder of Foresight Diagnostics, commented, “Our mission at Foresight Diagnostics is to improve the lives of cancer patients by developing ultra-sensitive assays for MRD detection. We’re excited to showcase our technology at AACR and we welcome the opportunity to connect with like-minded partners.” Poster Number 3375 / 18 will be presented in Session PO.CL01.16 on April 17, 2023, from 1:30 to 5:00 PM EST. About Foresight Diagnostics About PhasED-Seq Media contact information Phone: 720-443-3658
SOURCE Foresight Diagnostics |
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