Endo Pharmaceuticals Holdings Inc. Announces Pricing Of Common Stock Offering

CHADDS FORD, Pa., March 21 /PRNewswire-FirstCall/ -- Endo Pharmaceuticals Holdings Inc. announced today the pricing of a public offering of 10.5 million shares of its common stock by certain of its shareholders. The shares are being offered by Bear, Stearns & Co. Inc. as underwriter.

All of the shares are currently issued and outstanding except for 26,250 shares representing shares underlying outstanding stock options. Endo’s largest shareholder, Endo Pharma LLC, an affiliate of Kelso & Company (a private equity investment firm), is selling the majority of the shares being sold. Certain members of management have an ownership interest in Endo Pharma LLC. Shares are also being sold by certain current and former members of management and directors of Endo.

Following completion of the offering, Endo Pharma LLC will hold less than 1.0% of Endo’s outstanding common stock. Endo, which has approximately 133 million shares outstanding, will not receive any of the proceeds from this offering.

A shelf registration statement relating to these securities became effective upon filing with the Securities and Exchange Commission. This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state.

When available, a final prospectus related to the offering may be obtained by contacting Bear, Stearns & Co. Inc., Prospectus Department, 383 Madison Avenue, New York, NY 10179 (631-254-7129).

About Endo

Endo Pharmaceuticals Holdings Inc. is a fully integrated specialty pharmaceutical company with market leadership in pain management products. Through its Endo Pharmaceuticals Inc. subsidiary, the company researches, develops, produces and markets a broad product offering of branded and generic pharmaceuticals, meeting the needs of healthcare professionals and consumers alike.

Forward-Looking Statements

This press release contains forward-looking statements, within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, as amended, that are based on management’s beliefs and assumptions, current expectations, estimates and projections. Statements that are not historical facts, including statements which are preceded by, followed by, or that include, the words “believes,” “anticipates,” “plans,” “expects” or similar expressions and statements are forward-looking statements. Endo’s estimated or anticipated future results, product performance or other non- historical facts are forward-looking and reflect Endo’s current perspective on existing trends and information. Many of the factors that will determine the Company’s future results are beyond the ability of the Company to control or predict. These statements are subject to risks and uncertainties and, therefore, actual results may differ materially from those expressed or implied by these forward-looking statements. The reader should not rely on any forward-looking statement. The Company undertakes no obligation to update any forward-looking statements whether as a result of new information, future events or otherwise. Several important factors, in addition to the specific factors discussed in connection with these forward-looking statements individually, could affect the future results of Endo and could cause those results to differ materially from those expressed in the forward-looking statements contained in this press release. Important factors that may affect future results include, but are not limited to: market acceptance of the Company’s products and the impact of competitive products and pricing; dependence on sole source suppliers; the success of the Company’s product development activities and the timeliness with which regulatory authorizations and product launches may be achieved; successful compliance with extensive, costly, complex and evolving governmental regulations and restrictions; the availability on commercially reasonable terms of raw materials and other third party manufactured products; exposure to product liability and other lawsuits and contingencies; dependence on third party suppliers, distributors and collaboration partners; the ability to timely and cost effectively integrate acquisitions; uncertainty associated with pre- clinical studies and clinical trials and regulatory approval; uncertainty of market acceptance of new products; the difficulty of predicting FDA approvals; risks with respect to technology and product development; the effect of competing products and prices; uncertainties regarding intellectual property protection; uncertainties as to the outcome of litigation; changes in operating results; impact of competitive products and pricing; product development; changes in laws and regulations; customer demand; possible future litigation; availability of future financing and reimbursement policies of government and private health insurers and others; and other risks and uncertainties detailed in Endo’s filings with the Securities and Exchange Commission, including its Registration Statement on Form S-3 filed with the SEC on March 21, 2006. Readers should evaluate any statement in light of these important factors.

Endo Pharmaceuticals Holdings Inc.

CONTACT: Bill Newbould, Endo Pharmaceuticals, +1-610-558-9800

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