High blood levels of C-reactive protein, a substance linked to inflammation, appear to be associated with an increased risk for age-related macular degeneration, according to a report in the October issue of Archives of Ophthalmology, one of the JAMA/Archives journals.Age-related macular degeneration or aging macula disorder (AMD) occurs when the macula, the area at the back of the retina involved in sharp vision, deteriorates over time. Inflammation appears to play a role in the development of AMD, according to background information in the article. Proteins associated with inflammation, such as fibrinogen and C-reactive protein, have been found in drusen—the white deposits below the retina that are a hallmark of AMD.