SAN DIEGO, Sept. 8 /PRNewswire-FirstCall/ -- Discovery Partners International, Inc. (Nasdaq: DPII - News) today announced that its board of directors has approved a 4-to-1 reverse split of its common stock, subject to approval of an amendment to Discovery Partners’ charter to effect the reverse split by Discovery Partners’ stockholders at the special stockholders’ meeting to be held on September 12, 2006 related to Discovery Partners’ merger with Infinity Pharmaceuticals, Inc.