DILIsym Awarded $1.5 Million Phase II NIH Grant

Brett Howell, Ph.D., president of DILIsym Services, commented: “Our success with Phase I of this Fast-Track NIH grant demonstrates our commitment to help modernize drug development and reduce the time and costs associated with developing new therapies. With this continued NIH grant funding support, we will produce the first commercial version of RENAsym. Our team is dedicated to the development of commercial versions of RENAsym for use by the pharmaceutical industry, academic centers, and government agencies for investigation and screening of possible drug-induced kidney damage.”

In parallel with, and at the conclusion of the grant funding, the RENAsym Consortium is being formed to unite the world’s leading biopharmaceutical companies within a pre-competitive arena to collaborate, share ideas, and guide future development of RENAsym. This new consortium is patterned after DILIsym Services’ highly successful DILI-sim Initiative, which has developed tools to predict and understand drug-induced liver injury. RENAsym will utilize the PBPK module from GastroPlus^®, the industry leading PBPK modeling software, and eventually be offered as a module integrated into the GastroPlus platform (as well as in a standalone format).

Contact us to join the RENAsym Consortium today!

About DILIsym Services, Inc.

DILIsym Services Inc. was founded in 2015 in Research Triangle Park, North Carolina, and is the leading provider of drug-induced liver injury simulation software and related consulting services to the pharmaceutical industry. The company spun out of the former Hamner Institutes, acquiring all of the intellectual property, software, documentation, and other materials for the DILIsym^® software, a platform for predicting drug-induced liver injury. The company’s other products include MITOsym^®, for simulating in vitro mitochondrial function, and NAFLDsym^® for the study of nonalcoholic fatty liver disease – a worldwide disease with few available treatment options. More information is available on the company’s website at https://www.dilisym.com.

About Simulations Plus, Inc.

Simulations Plus Inc. is a premier developer of drug discovery and development software as well as a leading provider of both preclinical and clinical pharmacometric consulting services for regulatory submissions. The company is a global leader focused on improving the ways scientists use knowledge and data to predict the properties and outcomes of pharmaceutical and biotechnology agents. Our software is licensed to and used in the conduct of drug research by major pharmaceutical and biotechnology companies and regulatory agencies worldwide. Our innovations in integrating new and existing science in medicinal chemistry, computational chemistry, pharmaceutical science, biology, and physiology into our software have made us the leading software provider for physiologically based pharmacokinetic modeling and simulation. For more information, visit our website at www.simulations-plus.com.

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