SAN DIEGO--(BUSINESS WIRE)--Nov. 16, 2005--Cytori Therapeutics, Inc. (Frankfurt:XMPA), today presented results demonstrating that adipose-derived adult stem and regenerative cells improved blood flow to the site of injury in a preclinical model of a severe heart attack. These data demonstrate a significant increase in capillary density, a measure of the amount of oxygenated blood supplied to surrounding tissue, and support previously reported results that adipose-derived adult stem and regenerative cells enhance cardiac function. The results of the study were presented at the American Heart Association Scientific Sessions 2005 in Dallas, TX. (abstract no. 1386). In a randomized study, autologous adipose stem and regenerative cells (treated) or saline (control) were delivered into the left ventricular chamber, an approximation of intracoronary delivery. After twelve weeks, the capillary density in the treated group was greater than 40% than in the control group at the border zone, the site immediately adjacent to the injury. Capillary density is recognized as a measure of the quality of tissue perfusion and has been shown to decrease significantly in border zone following a heart attack. Increased perfusion helps to reduce progression of a heart attack into more severe cardiovascular disease.
