SOUTH SAN FRANCISCO, CA--(Marketwire - April 29, 2008) - Cytokinetics, Incorporated (NASDAQ: CYTK) announced today the initiation of its second Phase IIa clinical trial evaluating CK-1827452, a novel cardiac myosin activator being developed by the company for the potential treatment of patients with either acutely decompensated or chronic heart failure. CK-1827452 is the subject of a collaboration and option agreement between Cytokinetics and Amgen Inc.