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Amsterdam, NL - 10th April 2019: Technology innovators in super-resolution microscopy, Amsterdam-based Confocal.nl, launch new Re-scan Confocal Microscopy modules at the 2019 Focus on Microscopy meeting, London, UK.
New Re-scan Confocal Microscopy modules from Confocal.nl are the feature of Booth 76 at this year’s Focus on Microscopy conference and exhibition being held at the QEII Centre in London, April 14-17.
With the theme of “Improve Your Imaging Experience,” Confocal.nl will feature the next generation of Re-scan Confocal Microscopy (RCM) modules. Describing this new technology, co-founder and CTO, Dr Erik Manders says “We have taken our ground-breaking RCM module and doubled its field of view, upped its scan speed by 4x, integrated optimised deconvolution with the SVI Huygens software and introduced scanning in z. We are also pleased to announce the release of our infrared RCM module, the RCM-NIR.”
For those unable to attend the Focus on Microscopy (FOM2019) meeting, Confocal.nl are holding open-house demonstrations in their new office premises in The Netherlands on April 25. Located at the Science Park 106, 1098XG just minutes from the centre of Amsterdam, co-founder and CEO, Peter Drent, invites researchers to get an interactive demonstration of the new RCM modules. Drent says “we are pleased to collaborate with Nikon and Hamamatsu inviting folks to come and see new instrumentation in our custom-designed premises. Nikon is providing one of their Eclipse Ti2 microscopes while Hamamatsu will provide one of their Orca Flash 4 cameras. The demonstration will clearly show our commitment to excellence in imaging for the microscopy community. An example of this performance is shown here.”
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“With our new modules we address some limitations that we had in the past regarding (1) field of view, (2) imaging speed, (3) spectral domain and (4) resolution. This is how we have approached these four key points:
(1) The classical way to increase the field of view is by image stitching (by use of an automatic scanning stage). For researchers who do not have this, we have created the new LARGE field of view option. The result is a regular confocal image (240 nm resolution) with twice the field of view of a regular RCM image.
(2) in order to increase the scanning speed, we have created the new FAST option. This gives 2 to 4 times increase in speed. Imaging speed of around 4 fps can be achieved. This provides full 170 nm resolution RCM imaging.
(3) in order to widen the spectral domain, we have created the RCM-NIR. This is a super resolution confocal microscope that is optimized to work in the 600 - 950nm wavelength domain. It offers Z-sectioning and improved (40%) spatial resolution. Because of lower scattering in the NIR domain, the system is not only suited for deep imaging but is also ready for the newest generation of fluorescent dyes and fluorophores.
(4) Now we offer a dedicated RCM optimized deconvolution solution that increases the regular RCM resolution (170 nm) to a stunning 120 nm resolution!”
To learn about the Confocal.nl RCM module and how it may be configured into a high-performance scanning confocal imaging system, please visit www.confocal.nl. This includes a detailed video describing the principle of RCM.
For a high-resolution copy of the image, either right click to download or contact Jezz Leckenby at Talking Science Limited.
Acknowledgement for the sample
Representative nuclear spread from fixed mouse spermatocytes, immunostained for SYCP3, a component of the synaptonemal complex (Alexa 488-labelling) imaged with RCM using without re-scanning (confocal) and with re-scanning (RCM). Left: full spread. Right: individual chromosomes.
The sample is courtesy of A Agostino from the Advanced Light Microscopy Facility, Science for Life Laboratory and C Hogg of the Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm. Imaging and deconvolution by Erik Manders (Confocal.nl). For deconvolution, SVI Huygens software with RCM module was used.
About Confocal.nl
At Confocal.nl, we deliver turnkey solutions for the microscopist wanting the best confocal microscope. Applying Re-scan Confocal Microscopy (RCM) developed by Dr Erik Manders, CTO at Confocal.nl, we bring a new approach to provide better, no-nonsense microscopy solutions to the market in partnership with experienced microscopy entrepreneur, Peter Drent. Erik explains how we do it.
“The team at Confocal.nl has extensive experience in the field of microscopy, both in terms of technology and commercial acumen. We have learned to listen to colleagues and clients. We believe we are able to deliver accessible, easy-to-use solutions with better resolution, sensitivity and reproducibility. We also believe that users of microscopy want to have improved confocal microscopy performance at a price that is equally accessible to them. When we talk to prospective users about their confocal expectations, we start by finding out about their current instrumentation. This core information enables us to propose a custom-designed solution at a most affordable price point. Why dispose of perfectly functioning fluorescent microscopes, cameras and lasers when you can upgrade their performance with our Re-scan Confocal Microscopy module? From our growing, worldwide user base, we are confident we have found the best approach: to deliver a turnkey solution using our unique technology where we maximize photon collection and do so at a price a fraction of buying other commercial 3D confocal imaging solutions.”
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Confocal.nl
Science Park 106
1098XG Amsterdam
The Netherlands
T +31 (0)6 5054-3244
www.confocal.nl
peter@confocal.nl
Twitter - @confocal.nl
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Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA
T +44(0)1799 521881
M +44(0)7843 012997
www.talking-science.com
jezz@talking-science.com
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