BOSTON--(BUSINESS WIRE)--Jan. 30, 2006--CombinatoRx, Incorporated (NASDAQ: CRXX) today announced positive preliminary results of its randomized, blinded, placebo-controlled phase 2 clinical trial of CRx-102 in patients with osteoarthritis (OA) of the hand. The study met its primary endpoint of improvement in the AUSCAN visual analogue pain scale. Analysis of the primary endpoint shows mean change from baseline in the CRx-102 group was -102.4mm (a 33% improvement in pain) compared to mean change from baseline in the placebo group of -30.9mm (a 10% improvement). This improvement in pain was statistically significant with p=0.006. CRx- 102 is a novel synergistic combination drug candidate discovered and developed by CombinatoRx using CombinatoRx’s combination high throughput screening technology.