Targeting a biological signaling channel may relieve osteoarthritis and other joint-related complications by “working out” cartilage, a biological substance that has so far been notoriously difficult to stimulate and regrow. Articular cartilage is a type of flexible connective tissue that allows smooth movement of our hips, knees, shoulders, and other joints. Breakdown resulting from injury or overuse can lead to osteoarthritis — a debilitating wear-and-tear condition characterized by joint pain, tenderness, stiffness, and loss of flexibility. Unfortunately, such complications are often permanent, as cartilage is extremely difficult to repair.
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