WILMINGTON, Mass., Oct. 24 /PRNewswire-FirstCall/ -- CardioTech International, Inc. (Amex: CTE - News), a developer and manufacturer of advanced materials and medical devices for the treatment of cardiovascular and other diseases, today reported that it has signed a supply and royalty agreement with a leading developer and manufacturer of orthopedic devices. Under the terms of the in-perpetuity agreement, the Company provides exclusive use and supply of its proprietary ChronoFlex® polymer material that is specifically formulated for the development of orthopedic implant devices.