Caffeine intake makes insulin more resistant to changes in blood sugar levels, Canadian researchers report. This effect was observed both in patients with and those without diabetes and could not be reversed with regular exercise or weight.But before you throw away your coffee mug -- these results may not apply to the popular caffeinated beverage, the investigators note. In fact, previous research has suggested that drinking coffee may cut the risk of diabetes.When sugar levels in the blood get too high, insulin is released, which brings the levels back down. With insulin resistance, also known as decreased insulin sensitivity, sugar levels need to get much higher before insulin release is triggered. Over time, this resistance can cause problems and lead to diabetes.