An international team of researchers led by Boston University School of Medicine (BUSM) has identified four loci that appear to be associated with decreasing the volume of the hippocampus. The hippocampus is the region of the brain that plays an important role in the formation of specific, new memories, which is an ability that patients with Alzheimer’s disease lose. The findings may have broad implications in determining how age, Alzheimer’s disease and other diseases impact the function and integrity of the hippocampus.