Mission Bay supporters have said for years that a biotech commercial district would eventually grow up around the UCSF campus. But five years after UCSF broke ground at the highly touted development site, that hasn’t happened. There are no biotech companies at Mission Bay or anywhere else in San Francisco. The opening next month of the $72 million J. David Gladstone Institutes building, a center for biomedical research, might begin to change that. Gladstone is the first major nonresidential, non-UCSF enterprise to plant its flag at Mission Bay. Its arrival could mean that the time has finally come for the project’s large commercial component, development officials say.