the world’s leading chemical vendor BOC Sciences announced to upgrade its chiral analysis and separation service for the pharmaceutical industry to support scientists’ needs arising from drug testing after all the preliminary work of lead discovery in the early stages.
On July 16, 2019, the world’s leading chemical vendor BOC Sciences announced to upgrade its chiral analysis and separation service for the pharmaceutical industry to support scientists’ needs arising from drug testing after all the preliminary work of lead discovery in the early stages.
Chirality exists universally in many substances in nature like nucleic acids, starch, cellulose, proteins, and amino acids. As axially chiral biaryls is one of the most important activity structures of many drug molecules, it is necessary to employ techniques of chiral synthesis in the drug discovery process, so as to get the most ideal pharmaceutical products or other biologically active substances.
“After the lead candidates are identified and readily prepared, the next step is to carry out more researches on the physicochemical properties of those candidates,” says Mr. Barron Jones, the Marketing Chief of BOC Sciences. “Many studies have shown that single-configuration chiral molecule is usually a stereoisomer that has utility value, but its mirror image molecule is useless or even harmful. Considering this, it is very necessary for researchers to figure out the physicochemical properties of chiral substances that are enantiomers to each other. Our ultimate goal is to obtain a single chiral enantiomer that is beneficial to the human body and the environment.”
A range of modern analytical devices and methods are used in chiral analysis and separation, including high performance liquid chromatography (HPLC), gas chromatography (GC), capillary electrophoresis (CE), sensor methods, supercritical fluid chromatography (SFC), spectrometry and more. Chiral separation is widely used in analyzing chemical drugs designed for human disease treatment and in analyzing fine chemicals such as insecticides, fungicides, insect sex pheromones, food additives, plant growth regulators, and spices.
While different chiral compounds like chiral auxiliaries, chiral building blocks, chiral catalysts, and chiral ligands can be synthesized, those chemicals also need to be separated for further analysis. Despite the successful application of advanced chiral HPLC methods and isolation techniques as well as the use of low temperature to improve chiral separations in production analysis, there are still some challenges and frustrations in the separation and analysis of chiral agrochemicals.
“Against this backdrop, BOC Sciences offers state-of-the-art HPLC, GC, CE, and SFC equipment, as well as a dedicated team of experts to fully engage with chiral analysis and separation services for our customers. We are capable of isolating small quantities of individual enantiomers from new compounds for research evaluation,” adds Mr. Jones.
For more information about BOC Sciences’ chiral analysis and separation service, please visit: https://www.solutions.bocsci.
About BOC Sciences
Striving to become a trust-worthy brand in the past two decades, BOC Sciences has now shifted its focus to offer strategies and solutions in addressing the industry’s most pressing drug development issues. To this end, it provides comprehensive medicinal chemistry and drug testing service, building block synthesis, custom synthesis, analysis/purification, formulation services for pharmaceutical companies engaged in drug discovery and research.