EMERYVILLE, Calif., Sept. 24 /PRNewswire-FirstCall/ -- Bionovo, Inc. today announced that Dr. Elise Saunier, a Research Scientist at Bionovo, will present the results of a study on the effects of two plant-derived, tissue-selective estrogen receptor alpha (ERa) modulators (TSERaM) for obesity at the 20th Annual Meeting of the North American Menopause Society (NAMS) in San Diego on Friday, October 2nd.
In this study, ovariectomized female mice, mimicking menopause, were placed on a high fat diet for one month prior to initiation of treatment. While the untreated mice continued to gain weight, the mice administered with estrogens or the plant-derived TSERaMs lost weight. While estrogens had positive effects on the body fat mass, they significantly increased the size of the mammary gland and uterus. In contrast, the same tissues in the plant-derived TSERaM-treated mice closely resembled those of the untreated mice. These findings suggest that the development of botanically-derived, tissue-selective ERa modulators could result in a safer alternative for the treatment of menopausal weight gain and the prevention of metabolic syndrome and its associated risks.
Bionovo, Inc.
Bionovo, Inc. is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, markets with significant unmet needs and billions in potential annual revenue. The company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action. Based on the results of early and mid-stage clinical trials, Bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets. Bionovo is headquartered in Emeryville, California and is traded on the NASDAQ Capital Market under the symbol, "BNVI". For more information about Bionovo and its programs, visit: http://www.bionovo.com.
Bionovo, Inc.
