Gene-expression profiles might be used to identify prognostic biomarkers for Kawasaki disease, and help to unravel the underlying biology of the illness, research published this week in the online open access journal Genome Biology reveals. The new findings also support the idea that gene-expression profiles might be used to generate biomarkers for other systemic inflammatory illnesses.Kawasaki disease, an acute, self-limited vasculitis, is the leading cause of acquired heart disease in children in developed countries, but its aetiologic and pathogenic mechanisms remain unclear.
