Dr. Peter Simon Joins SYGNIS Pharma AG as VP Business Development

Heidelberg, March 3 2008 –SYGNIS Pharma AG (Frankfurt: LIO; ISIN DE0005043509; Prime Standard), today announced that it has appointed Dr. Peter Simon to the newly-created role of VP Business Development.

Prior to joining SYGNIS Dr. Simon, 49, held the position of Senior Director, Business Development at Jerini AG and was responsible for the out-licensing and partnering of their lead product, Icatibant, in Europe, Asia and Latin-America. He has over 19 years’ experience of international business development within the pharmaceutical and biotechnology industry and has held senior positions at Nycomed, Merz + Co., Smith-Kline Beecham and Klinge-Fujisawa. At SYGNIS Dr. Simon will be responsible for developing and implementing the commercial strategies with regard to the Company’s innovative development-stage CNS compounds and in-licensing of promising product candidates.

Dr. Alfred Bach, CEO of SYGNIS Pharma AG, said: “Peter’s substantial business development expertise will guide SYGNIS’ partnering activities as we seek to maximise the value of our innovative CNS pipeline, through this new role at the Company. We are delighted to welcome him to our management team and to SYGNIS.”

About SYGNIS Pharma

SYGNIS Pharma AG, with head offices in Heidelberg, is a specialty pharmaceutical Company listed on the Prime Standard of the German stock exchange. The Company is focused on the research, development and marketing of innovative therapies for the treatment of neurodegenerative diseases. These include stroke, Amyotrophic Lateral Sclerosis (ALS) and neurological disorders resulting from injuries of the brain or spinal cord. All these disorders are characterized by the fact that, as the disease progresses, nerve cells are damaged and die. Although there is great medical demand, there are currently no or only inadequate treatment options available.

For further information please contact:

SYGNIS Pharma AG: Dr. Franz-Werner Haas Vice President Operations +49 (0) 6221 454 812 franz-werner.haas@sygnis.de

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