Research article in the journal NanoMedicine cites Biotech Support Group’s Cleanascite™ sample preparation reagent to obtain lipid clarified c-Myc inhibitor prodrug used in a drug delivery and enzymatic release platform.
PRLog - Feb. 10, 2015 - MONMOUTH JUNCTION, N.J. -- MONMOUTH JUNCTION, NJ – A research article in the journal NanoMedicine (http://www.ncbi.nlm.nih.gov/pubmed/25600969) cites Biotech Support Group’s Cleanascite (http://biotechsupportgroup.com/node/73/)™ sample preparation reagent for two separate clarifications. The study evaluated the development of a phospholipid encapsulated c-Myc inhibitor prodrug and its potential use to prevent melanoma. The article states:
“125 µl of c-Myc NPs was mixed with 375 µl of Cleanascite™ and incubated for approximately 30 min at room temperature (RT) then centrifuged for 10 min at 5000 rpm. ...” and “The plasma-enzyme-NP mixture (200 µl) was combined with 200 µl Cleanascite (http://biotechsupportgroup.com/node/73/)™ for lipid removal and clarification (Biotech Support Group, Inc., NJ, USA) at 25°C for 15 min.”
“Background lipids can create artifactual errors when measuring the activity of lipase enzymes from serum or plasma. I am pleased to see that the selectivity profile of Cleanascite (http://biotechsupportgroup.com/node/73/)™ supports such important cancer related applications.”, states Dr. Swapan Roy, President & Founder of Biotech Support Group.
About Biotech Support Group LLC
Biotech Support Group LLC is a leading provider of proteomic, metabolomic and genomic sample preparation and enrichment products and services. It’s principal products include: AlbuVoid™ & AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ for nucleic acid isolation. For more information, go to http://www.biotechsupportgroup.com
Contact:
Dr. Swapan Roy & Matthew Kuruc
Biotech Support Group LLC
1 Deer Park Drive, Suite M
Monmouth Junction NJ 08852
732-274-2866 Worldwide
800-935-0628 North America
sales@biotechsupportgroup.com
http://www.biotechsupportgroup.com
Reference
Pan, Dipanjan, et al. “A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. (http://www.futuremedicine.com/doi/abs/10.2217/nnm.14.101)” Nanomedicine 10.2 (2015): 241-251.
Suggested References
Dang, Chi V., et al. “Function of the c-Myc oncogenic transcription factor.” Experimental cell research 253.1 (1999): 63-77.
Zhuang, D., et al. “C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.” Oncogene 27.52 (2008): 6623-6634.
Wang, H., et al. “c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle. (http://www.nature.com/onc/journal/v27/n13/abs/1210823a.html)” Oncogene 27.13 (2008): 1905-1915.
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Biotech Support Group
***@biotechsupportgroup.com
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