Aruvant Sciences, a private company focused on developing gene therapies for rare diseases, announced new data demonstrating the potentially curative effect of ARU-1801 as a one-time investigational gene therapy for sickle cell disease (SCD) during an oral presentation at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition.
NEW YORK, Dec. 7, 2020 /PRNewswire/ -- Aruvant Sciences, a private company focused on developing gene therapies for rare diseases, announced new data demonstrating the potentially curative effect of ARU-1801 as a one-time investigational gene therapy for sickle cell disease (SCD) during an oral presentation at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition. Michael S. Grimley, M.D., Professor of Clinical Pediatrics, Medical Director of the Division of Bone Marrow Transplantation and Immune Deficiency at the Cincinnati Children's Hospital Medical Center, is presenting the data today, December 7, 2020, at 2:15 PM PT. "ARU-1801 demonstrated clinically meaningful long-term reductions in sickle cell disease burden," said Dr. Grimley. "The potentially curative efficacy seen from the new manufacturing process and three year durability demonstrated by the first treated patient show that ARU-1801, given with only reduced intensity conditioning, can be an important and more tolerable treatment option for patients with severe SCD." ARU-1801 is designed to address the limitations of current curative treatment options, such as low donor availability and the risk of graft-versus-host disease (GvHD) seen with allogeneic stem cell transplants. Unlike investigational gene therapies and CRISPR gene editing approaches which require fully myeloablative conditioning, the unique characteristics of ARU-1801 allow it to be given with reduced intensity conditioning ("RIC"). Compared to myeloablative approaches, the lower dose conditioning regimen underlying RIC has the potential to reduce not only hospital length of stay, but also the risk of short- and long-term adverse events such as infection and infertility. The data being presented today highlights participants dosed with product manufactured with both the original academic manufacturing process (Process I) and the enhanced Process II. ARU-1801 incorporates a modified gamma-globin gene into autologous stem cells, with the aim of restoring normal red blood cell function through increased levels of fetal hemoglobin. The high potency of the modified gamma globin enables ARU-1801 to engraft using RIC. Highlights of the data:
The MOMENTUM Study About Aruvant Sciences About Roivant
SOURCE Aruvant Sciences |