SYGNIS Pharma AG Announces Management Board Changes

Heidelberg, March 25, 2013 - SYGNIS Pharma AG (Frankfurt: LIO1; ISIN: DE000A1RFM03, Prime Standard), today announced that Chief Financial Officer (CFO) and member of the Management Board, Peter Willinger will be stepping down effective 31 March 2013 for personal reasons. He is leaving the company by mutual agreement with the Supervisory Board. Pilar de la Huerta, the company's CEO since 2012 and a former senior manager and CFO at Zeltia, S.A., the largest Spanish quoted biotech company, will now hold both positions, CFO and CEO.

For further information please contact:

SYGNIS Pharma AG

Pilar de la Huerta

CEO/CFO

Tel: +34-918063089

Email: pdelahuerta@sygnis.es

Disclaimer

This publication is intended for information only and constitutes neither an offer to sell nor an invitation to buy securities. Some statements included in this press release, relating neither to proven financial results nor other historical data, should be viewed as forward-looking, i.e. not definite. Such statements are mainly predictions of future results, trends, plans or goals. These statements should not be considered to be total guarantees since given their very nature they are subject to known and unknown risks and imponderability and can be affected by other factors as a consequence of which the actual results, plans and goals of SYGNIS Pharma AG may deviate greatly from the established conclusions or implied predictions contained in such statements. SYGNIS does not undertake to publicly update or revise these statements in the light of new information or future results or for any other reason.