ReShape Lifesciences™ Announces Positive Preclinical Results for Its Investigational Diabetes Bloc-Stim Neuromodulation Device
SAN CLEMENTE, Calif., Sept. 10, 2020 /PRNewswire/ -- ReShape Lifesciences (Formally known as EnteroMedics) Inc., (OTCQB: RSLS) a global weight-loss solutions leader, today announced preclinical research demonstrating the Company's investigational Diabetes Bloc-Stim Neuromodulation™ (DBSN™) proprietary device for the treatment of type 2 diabetes mellitus (T2DM) was well-tolerated and met the study endpoints. The study was conducted as a part of the National Institutes of Health (NIH) Small Business Innovation Research Phase I grant that was previously awarded August 1, 2019.
The preclinical investigation consisted of simultaneous electrical blockade and stimulation of individual vagal nerve branches and was conducted in a type 2 diabetic porcine animal model. Results showed a significant reduction of blood glucose. Histopathology of organ systems effected by the neuromodulation demonstrated healthy tissue. These findings broaden the proof-of-concept and mechanism of action, results of which were initially presented at ObesityWeek 2018. Further demonstrating that dual vagus nerve neuromodulation – a novel and proprietary approach - improves glycemic control in animal models of T2DM.
"Bioelectronic medicine represents a growing and exciting field as it supports the potential for less dependence on drug therapy and addresses the challenges associated with daily compliance for those suffering from diabetes," said Bart Bandy, President & CEO of ReShape Lifesciences Inc. "Our exploration of neuromodulation for diabetes aligns with the ReShape Lifesciences™ corporate strategy to build our portfolio and pipeline with technologies and services that improve the treatment of obesity and metabolic diseases. Based on these positive outcomes, the preclinical study represents a successful completion of the NIH Phase I grant and we look forward to advancing this unique diabetes focused innovation."
"The ReShape Lifesciences Diabetes Bloc-Stim Neuromodulation technology has accomplished key goals through the NIH Phase I Small Business Innovation Research grant study. The preliminary data strongly calls for pursuit of further evaluating this treatment for type 2 diabetes mellitus," said Charles Billington, M.D., Chief of Endocrinology at the VA Medical Center in Minneapolis, MN and Professor of Medicine at the University of Minnesota, and the lead advisor in the ReShape Lifesciences preclinical diabetes research program.
Research reported in this press release was supported by National Institute of Diabetes and Digestive and Kidney Diseases of the NIH under award number 1R43DK122846-01. The NIH award for this research was $299,048. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
About ReShape Lifesciences Inc.
ReShape Lifesciences is America's premier weight-loss solutions company, offering an integrated portfolio of proven products and services that manage and treat obesity and metabolic disease. The FDA-approved Lap-Band® program provides minimally invasive, long-term treatment of obesity and is an alternative to more invasive surgical stapling procedures such as the gastric bypass or sleeve gastrectomy. The ReShape Vest™ System is an investigational (outside the U.S.) minimally invasive, laparoscopically implanted medical device that wraps around the stomach, emulating the gastric volume reduction effect of conventional weight-loss surgery. It helps enable rapid weight loss in obese and morbidly obese patients without permanently changing patient anatomy. The recently launched ReShapeCare™ Virtual health coaching program is a virtual tele-health weight management program that supports lifestyle changes for all weight-loss patients, to help them keep the weight off over time.
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SOURCE ReShape Lifesciences Inc.
Company Codes: OTC-PINK:RSLS, OTC-QB:RSLS