Health Data Analytics Institute (HDAI) – an innovator in healthcare AI solutions – and researchers at Dana-Farber Cancer Institute today announced publication of findings exploring the effectiveness of immune checkpoint inhibition for the treatment of Medicare patients with lung cancer.
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BOSTON, May 21, 2021 /PRNewswire/ -- Health Data Analytics Institute (HDAI) – an innovator in healthcare AI solutions – and researchers at Dana-Farber Cancer Institute today announced publication of findings exploring the effectiveness of immune checkpoint inhibition for the treatment of Medicare patients with lung cancer. The study, titled "Association between first-line immune checkpoint inhibition and survival for Medicare patients with advanced non-small cell lung cancer," is posted in the Journal of the American Medical Association (JAMA) Network Open. HDAI and Dana-Farber Cancer Institute study of 20,000 Medicare patients finds shorter survival than clinical trials show
Immunotherapy is now a cornerstone of treatment for advanced non-small cell lung cancer (NSCLC), but its uptake and effectiveness among older patients outside of clinical trials remains poorly understood. In partnership with Dana-Farber, HDAI conducted a large, real-world evidence study of nearly 20,000 Medicare patients, age 66-89, receiving first line treatment of advanced NSCLC with either immunotherapy, chemotherapy, or a combination of both. The study looked at risk-adjusted restricted mean survival times from patients treated in 2016-2018, with survival follow-up continuing through March 31, 2020. The median overall survival was 11.4 months among patients receiving immunotherapy alone, which is about 15 months less than reported in a prior clinical trial. The adjusted restricted mean survival time through 18 months of follow-up was 11-13 months for all treatment groups, including those receiving chemotherapy alone. "These results, based on the nationwide experience for patients on Medicare, may inform discussions between physicians and patients with respect to expectations for outcomes among older patients with non-small cell lung cancer," said Kenneth L. Kehl, MD, MPH Assistant Professor of Medicine at Harvard Medical School and the study's first author. He noted that "the shorter survival times observed in the Medicare population may reflect the treatment of older patients with higher burdens of frailty and comorbidity." Deborah Schrag, MD, MPH, the study's senior author and Chief of the Division of Population Sciences at Dana-Farber and Harvard Medical School noted "this information empowers patients and clinicians with realistic expectations and equips them to make informed decisions. Evaluation of Medicare claims data is an expedient approach to measuring real world outcomes." "Immunotherapy holds significant promise as a relatively new treatment option," said Nassib Chamoun, HDAI's CEO and founder. "That said, it is important to understand how well results from carefully controlled trials generalize to the more vulnerable Medicare population in order to optimize treatment selection and facilitate informed treatment discussions. We hope this research encourages additional conversations about the importance of biomarkers and markers of comorbidity in the evolution of personalized care for patients with lung cancer." About Dana-Farber Cancer Institute: As a global leader in oncology, Dana-Farber is dedicated to a unique and equal balance between cancer research and care, translating the results of discovery into new treatments for patients locally and around the world, offering more than 1,100 clinical trials. About HDAI: Media Contact:
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