Moleculin Announces New Antiviral Drug Candidates Demonstrate In Vitro Activity Against HIV
HOUSTON, Oct. 6, 2020 /PRNewswire/ -- Moleculin Biotech, Inc., (Nasdaq: MBRX) (Moleculin or the Company), a clinical stage pharmaceutical company with a broad portfolio of drug candidates targeting significant unmet needs in the treatment of tumors and viruses, announced preliminary new findings from its research collaboration with the Rega Institute in Leuven, Belgium, that demonstrate its drug candidates, WP1096 and WP1097, are showing significant in vitro activity in a range of infectious diseases. In addition to activity against SARS-CoV-2, antiviral activity has now been documented for HIV, Zika and Dengue Fever.
WP1096 and its close analog, WP1097, are structurally slightly different agents within the Company's WP1122 portfolio. While the Company is continuing its preclinical development work on WP1122, including in vivo testing for SARS-CoV-2, it has now expanded its infectious disease program to include these two molecules. In addition, the Company continues to drive the clinical development of Annamycin, which is currently being studied for the treatment of relapsed or refractory acute myeloid leukemia, and WP1066, which targets brain tumors, pancreatic cancer and hematologic malignancies.
Walter Klemp, Chairman and CEO of Moleculin, stated, "We recently announced the discovery that these new molecules have significant in vitro activity in SARS-CoV-2 that may be due to mechanistic differences from other molecules in the WP1122 portfolio. Now, we are looking at the possibility that our portfolio of antimetabolites can address a wide range of infectious diseases beyond COVID-19."
Mr. Klemp continued, "In the case of Zika and Dengue Fever, there are no viable therapies, so we think this study garners the potential to involve possible governmental entities to assist in the development of and provide funding for the first ever treatments for these important diseases."
Mr. Klemp concluded, "Even though there is already a $20 billion US market for currently approved treatments for HIV, we believe that there is now a growing concern that drug resistance may begin to put more HIV patients at risk. We believe that our antimetabolites potentially represent an entirely new mechanism of action to the HIV therapeutic line-up. The significance to Moleculin shareholders is that we believe the business opportunity for Moleculin has now potentially gotten much bigger than just COVID-19."
About Moleculin Biotech, Inc.
Moleculin Biotech, Inc. is a clinical stage pharmaceutical company focused on the development of a broad portfolio of oncology drug candidates for the treatment of highly resistant tumors and viruses. The Company's clinical stage drugs are: Annamycin, a Next Generation Anthracycline, designed to avoid multidrug resistance mechanisms with little to no cardiotoxicity being studied for the treatment of relapsed or refractory acute myeloid leukemia, more commonly referred to as AML, WP1066, an Immune/Transcription Modulator capable of inhibiting p-STAT3 and other oncogenic transcription factors while also stimulating a natural immune response, targeting brain tumors, pancreatic cancer and hematologic malignancies, and WP1220, an analog to WP1066, for the topical treatment of cutaneous T-cell lymphoma. Moleculin is also engaged in preclinical development of additional drug candidates, including other Immune/Transcription Modulators, as well as WP1122 and related compounds capable of Metabolism/Glycosylation Inhibition.
For more information about the Company, please visit http://www.moleculin.com.
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SOURCE Moleculin Biotech, Inc.
Company Codes: NASDAQ-SMALL:MBRX