Milestone Scientific Schedules First Quarter Earnings Conference Call For Tuesday, May 16, 2006

LIVINGSTON, N.J., May 12 /PRNewswire-FirstCall/ -- Milestone Scientific Inc. , which develops, manufactures and markets computer controlled injection systems for medical and dental applications, today announced that it will host an investor conference call on Tuesday, May 16, 2006, to discuss its first quarter operating results and the outlook for the remainder of the year. The Company plans to report its first quarter operating results on Monday, May 15, 2006.

Shareholders and other interested parties may participate in the conference call by dialing 888-694-4702 (international/local participants dial 973-582-2741) and referencing the ID code 7388708, a few minutes before 11:00 a.m. EDT on Tuesday, May 16, 2006. A replay of the conference call will be available two hours after the completion of the conference call from May 16, 2006 until May 23, 2006 by dialing 877-519-4471 (international/local participants dial 973-341-3080) and entering the conference ID 7388708.

About Milestone Scientific Inc.

Milestone Scientific is the developer, manufacturer and marketer of CompuMed(R) and CompuDent(R) computer controlled injection systems for medical and dental applications. These systems comprise a microprocessor controlled drive unit as well as The Wand(R) handpiece, a single patient use product that is held in a pen-like manner for injections. The Company also sells the SafetyWand(R), which incorporates engineered sharps injury protection features to aid in the prevention of accidental needlesticks. Milestone has also developed proprietary consumer (Ionic White) and professional (Cool Blue) teeth whitening systems that were introduced to the market earlier this year.

In 2001, Milestone Scientific received broad United States patent protection on an enabling technology for computer controlled, pressure sensitive infusion, perfusion, suffusion and aspiration, which provides real time displays of pressures, fluid densities and flow rates, that advances the delivery and removal of a wide array of fluids. Development of this CompuFlo technology is currently underway.

The Company is headquartered in Livingston, New Jersey, and its common stock trades on the American Stock Exchange under the symbol "MSS".

This press release contains forward-looking statements regarding the timing and financial impact of the Milestone's ability to implement its business plan, expected revenues and future success. These statements involve a number of risks and uncertainties and are based on assumptions involving judgments with respect to future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond Milestone's control. Some of the important factors that could cause actual results to differ materially from those indicated by the forward-looking statements are general economic conditions, failure to achieve expected revenue growth, changes in our operating expenses, adverse patent rulings, FDA or legal developments, competitive pressures, changes in customer and market requirements and standards, and the risk factors detailed from time to time in Milestone's periodic filings with the Securities and Exchange Commission, including without limitation, Milestone's Annual Report on Form 10-KSB for the year ended December 31, 2005. The forward looking-statements in this press release are based upon management's reasonable belief as of the date hereof. Milestone undertakes no obligation to revise or update publicly any forward-looking statements for any reason.

CONTACT Leonard Osser, CEO Milestone Scientific Inc. (973) 535-2717; (973) 535-2829 (Fax) Web site: www.milesci.com

Milestone Scientific Inc.

CONTACT: Leonard Osser, CEO of Milestone Scientific Inc., +1-973-535-2717,or fax, +1-973-535-2829

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