EIP Pharma Announces Publication of Preclinical Results Demonstrating Potential of Neflamapimod to Promote Functional Recovery after Ischemic Stroke
BOSTON, Dec. 16, 2020 /PRNewswire/ -- EIP Pharma, Inc. (www.eippharma.com), a CNS-focused therapeutics company, announced today the scientific publication of preclinical results that demonstrate neflamapimod promotes functional recovery after ischemic stroke in rats. Entitled "Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level," the report was published in the journal PLOS ONE.
In the study neflamapimod was administered to rats at either 1.5 mg/kg or 4.5 mg/k twice daily for six weeks, starting 48-hours after stroke was induced via transient middle cerebral artery occlusion. The major findings showed that neflamapimod treatment, relative to vehicle treatment:
"While thrombolysis and thrombectomy have significantly improved the outcome for patients with acute ischemic stroke, because they are only effective when administered within the first small number of hours after the stroke, most patients are not eligible for such treatment. Combined with the failure of numerous other approaches to neuroprotection, there is growing interest in developing therapies to promote functional recovery after the completion of the acute stroke event," said John Alam, MD, the senior author of the publication and CEO of EIP Pharma.
Along with demonstrating the potential of neflamapimod to promote functional recovery through enhancing synaptic plasticity, the results of this study offer the possibility of having a therapy for stroke that could be initiated outside the short time window for neuroprotection. From a drug development perspective, starting treatment in a clinical study at 48 hours or later after stroke allows for the inclusion of more homogenous sub-populations of patient, thereby increasing the statistical power of clinical studies to detect treatment effects. As a result, the company believes definitive clinical-proof-of-concept could potentially be demonstrated with a less than 200-patient phase 2 clinical study that would evaluate the effects on functional recovery of three months neflamapimod treatment, starting in the first week after an acute ischemic stroke.
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Alam JJ, Krakovsky M, Germann U, Levy A (2020) Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose dependent functional recovery accompanied by increase in brain BDNF protein level. PLoS ONE 15(12): e0233073. https://doi.org/10.1371/journal.pone.0233073
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SOURCE EIP Pharma, Inc.