Antidepressant Seems To Help Smokers Quit

The antidepressant drug nortriptyline, when used with a nicotine patch, may help smokers kick the habit. Researchers from the University of Colorado Health Sciences Center offer that assessment in the November issue of the Archives of Internal Medicine. The study included a group of 79 people who received nortriptyline and another group of 79 people who received a placebo. Both groups started with 25 milligrams per day of either the drug or the placebo 14 days before the date set for them to stop smoking. The doses were then increased to 75 milligrams per day, as tolerated. All the study participants were given a transdermal nicotine patch on the day they quit smoking. All of them continued to use nicotine patches for eight weeks. Six months after the quit day, smoking-cessation rates were 23 percent for those taking nortriptyline and 10 percent for those taking the placebo. There was no reduction in withdrawal symptoms in either group. The people in the nortriptyline group had much higher rates of side effects such as dry mouth and drowsiness. Due to these adverse effects, nortriptyline was discontinued in 13 percent of the people taking it.