Antioxidant Treatment May Help NF1-Linked Behavioral Issues, Cincinnati Children’s Hospital Medical Center Study

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New research in mouse models suggests that treatment with antioxidants may help reduce behavioral issues linked to the genetic nervous system disorder Neurofibromatosis 1 (NF1) and an associated condition called Costello syndrome. Scientists from Cincinnati Children’s Hospital Medical Center report their findings Sept. 12 in Cell Reports. The authors show that defects in the NF1/Ras molecular pathway, which cause the disorders, trigger production of harmful oxidative nitric oxide molecules in the oligodendrocyte glial brain cells of mice.

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