Fremont CA – June 19, 2012 -- AnaSpec, EGT Group is pleased to provide a whole suite of reagents for the advancement of Alzheimer’s disease (AD) research. From peptides to assay kits to antibodies to dyes, AnaSpec is the trusted source of integrated proteomics solutions for AD research. Amongst the more than 300 ß-amyloid peptides, we offer ß-amyloid (1-40) and (1-42) that are HFIP treated.
ß-amyloids are amphiphilic peptides with a hydrophilic N-terminal domain (residues 1 to 28) and a hydrophobic C-terminal (residues 29 to 40-42), the latter corresponding to a part of the transmembrane domain of APP.1 ß-Amyloid assembly into fibrils is initiated by a conformational transition from random coil to ß-sheet (hence the name ß-amyloid) and a nucleation-dependent aggregation process.1 Aß peptides that are 39 to 42 amino acid residues in length with a molecular mass of approximately 4 kDa are the core components of neuritic plaques seen in Alzheimer’s disease (AD) brains. Studies have found that dissolving in HFIP favors alpha helical structure and tends to be monomeric.2 HFIP treatment of lyophilized Aß-peptide results in a dense, homogeneous preparation of unaggregated peptide and samples can be stored as peptide films.3
References
1. Jarrett, JT. et al. Biochem 32, 4693 (1993).
2. Barrow, CL. et al. J Mol Bio 225, 1075 (1992).
3. Stine, WB. et al. J. Biol. Chem., 278, 11612 (2003).
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AnaSpec, EGT Group
AnaSpec, Eurogentec Group is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.
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