CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today the publication of a new paper describing a novel technique called circulating Extracellular RNA Detection (cERD). The paper, titled “Tissue-specific gene silencing monitored in circulating RNA” (Sehgal et al., RNA, doi:10.1261/rna.042507.113) appears online as an Advance Article in the journal RNA. The cERD method enables the quantification of circulating messenger RNA (mRNA) and micro-RNA (miRNA) as a way of monitoring tissue-specific RNA silencing. It also enables confirmation of an RNAi-mediated mechanism of action using a PCR-based technique. The cERD method could have broad applicability in clinical studies since it allows for monitoring of tissue-specific mRNA levels using a non-invasive technique.
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